Modafinil-Induced Psychosis: A Case Report

Modafinil is used in the treatment of excessive day time sleepiness associated with several clinical conditions. It can also be used for affective stimulation for working late and/or concentrating for a long time. The reported cases of psychosis associated with modafinil use in the literature, have medical or psychiatric diorders. There is only one reported case without medical or psychiatric disorder but developed modafinil related psychosis, which is a case under simulated shift work in laboratory conditions. The cases in the literature are reported to develop mania or psychosis with 200-400 mg/day or higher doses. The case reported in this manuscript develop psychosis with 100 mg/day dosage. This case has no previous psychiatric and medical disorder history and not being on a shift work. The aim of modafinil use in this case was reported as increasing the concentration and performance while studying. Modafinil using patients must be psychiatrically monitored for its potential psychotic effect even in previously healthy individuals and low doses.