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Related Experiment Videos

Reducing dentine hypersensitivity with nano-hydroxyapatite toothpaste: a double-blind randomized controlled trial.

M Vano1, G Derchi1,2, A Barone3

  • 1Dept of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa, Pisa, Italy.

Clinical Oral Investigations
|April 1, 2017
PubMed
Summary

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Nano-hydroxyapatite toothpaste effectively reduces dentin hypersensitivity compared to fluoride toothpaste and placebo. This fluoride-free gel provides significant relief from tooth sensitivity within two to four weeks.

Area of Science:

  • Dentistry
  • Biomaterials Science

Background:

  • Dentin hypersensitivity is a common dental condition.
  • Effective desensitizing agents are crucial for improving oral health and patient comfort.

Purpose of the Study:

  • To compare the efficacy of nano-hydroxyapatite (nHA) toothpaste against fluoride toothpaste and a placebo in reducing dentin hypersensitivity.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial involving 105 participants.
  • Participants were assigned to three groups: nHA gel (2% fluoride-free), fluoride gel, or placebo.
  • Hypersensitivity was assessed using airblast, tactile tests, and a visual analogue scale (VAS) at baseline, 2, and 4 weeks.

Main Results:

  • The nHA group showed significantly lower cold air and tactile sensitivity at 2 and 4 weeks (p < 0.05).
Keywords:
Dentine hypersensitivityDesensitizing agentsFluorideNano-hydroxyapatite

Related Experiment Videos

  • Compared to both fluoride and placebo groups, the nHA group reported significantly lower sensitivity scores.
  • VAS scores significantly decreased in the nHA group at 2 and 4 weeks compared to baseline and control groups.

    • Conclusions:

    • Nano-hydroxyapatite in a fluoride-free gel toothpaste is an effective agent for reducing dentin hypersensitivity.
    • The nHA formulation provides significant symptomatic relief within 2 to 4 weeks of application.