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Antibody Response to Paramyxoviruses in Paget's Disease of Bone
Micaela Rios Visconti1, Ricardo Usategui-Martín1, Stuart H Ralston2
1The Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, UK.
Abstract:
Paget's disease of bone (PDB) is a common skeletal disorder characterised by focal abnormalities of increased and disorganised bone turnover. Genetic factors play a central role in the pathogenesis of PDB but environmental factors also contribute. Measles virus (MV), respiratory syncytial virus (RSV) and canine distemper virus (CDV) have all been implicated as potential disease triggers but the data are conflicting. Since chronic paramyxovirus infection with measles is known to be accompanied by increased production of antiviral antibodies, we have analysed circulating concentrations of antibodies to MV, CDV, and RSV as well as mumps, rubella and varicella zoster virus (VZV) in 463 patients with PDB and 220 aged and gender-matched controls. We also studied the relation between viral antibody concentrations and various markers of disease severity and extent in 460 PDB patients. A high proportion of cases and controls tested positive for antiviral antibodies but there was no significant difference in circulating antibody concentrations between PDB cases and controls for MV, CDV, RSV, rubella or VZV. However, mumps virus antibody levels were significantly higher in the PDB cases (mean ± SD = 3.1 ± 0.84 vs. 2.62 ± 0.86. p < 0.001). There was no association between disease severity and circulating antibody concentrations to any of the viruses. In conclusion, we found no evidence to suggest that PDB is associated with abnormalities of immune response to measles or other paramyxoviruses, although there was evidence of a greater antibody response to mumps. The results do not support that hypothesis that PDB is associated with a persistent infection with measles or other paramyxoviruses.
Insights
This study investigated Paget's disease of bone (PDB) and viral infections. While no link was found with measles or other paramyxoviruses, higher mumps virus antibody levels were observed in PDB patients.
Area of Science:
- Immunology
- Virology
- Bone Biology
Background:
- Paget's disease of bone (PDB) is a skeletal disorder with increased bone turnover, potentially influenced by genetic and environmental factors.
- Previous research has suggested a link between PDB and viral infections like measles, respiratory syncytial virus (RSV), and canine distemper virus (CDV), but findings are conflicting.
Purpose of the Study:
- To investigate the association between Paget's disease of bone (PDB) and immune responses to specific viral infections.
- To determine if circulating antibody concentrations to measles virus (MV), RSV, CDV, mumps, rubella, and varicella zoster virus (VZV) differ between PDB patients and controls.
- To explore the relationship between viral antibody levels and PDB severity.
Main Methods:
- Circulating antibody concentrations to MV, CDV, RSV, mumps, rubella, and VZV were measured in 463 PDB patients and 220 controls.
- Antibody levels were compared between cases and controls using statistical analysis.
- The correlation between viral antibody concentrations and PDB severity markers was assessed in 460 PDB patients.
Main Results:
- A high proportion of both PDB cases and controls tested positive for antiviral antibodies.
- No significant differences in antibody concentrations were found for MV, CDV, RSV, rubella, or VZV between PDB patients and controls.
- Significantly higher mumps virus antibody levels were detected in PDB cases compared to controls (p < 0.001).
- No association was observed between disease severity and antibody concentrations to any of the studied viruses.
Conclusions:
- The study found no evidence supporting an association between Paget's disease of bone (PDB) and immune response abnormalities to measles or other paramyxoviruses.
- A greater antibody response to mumps virus was observed in PDB patients, warranting further investigation.
- The findings do not support the hypothesis that PDB is linked to persistent infection with measles or other paramyxoviruses.