Vaccine Associated Paralytic Poliomyelitis Unmasking Common Variable Immunodeficiency
Sunil Gomber1, Vanny Arora, Pooja Dewan
1Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110095, India. Correspondence to: Dr Sunil Gomber, Director-Professor, Department of Pediatrics, Guru Teg Bahadur Hospital, Dilshad Garden. Delhi 110 095, India. sunilgomber@hotmail.com.
Background:
Oral polio vaccine can rarely lead to Vaccine-associated paralytic poliomyelitis (VAPP).
Case Characteristics:
A 2-year-old child with asymmetric paralysis of lower limbs following first booster of oral polio vaccine; type 2 Vaccine-derived poliovirus (VDPV) isolated. Subsequently, the child was diagnosed to have common variable immunodeficiency.
Outcome:
Paralysis gradually improved on follow-up; monthly intravenous immunoglobulin therapy started for primary immunodeficiency.
Message:
We need to evaluate children with VAPP for underlying immunodeficiency.
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