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Related Experiment Videos

Hippo interferes with antiviral defences.

Natalia Muñoz-Wolf1, Ed C Lavelle1,2

  • 1Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, D02 R590, Ireland.

Nature Cell Biology
|April 1, 2017
PubMed
Summary

The Hippo pathway, known for regulating organ size, also controls antiviral defense. It modulates TBK1-mediated interferon production to fight infections.

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Area of Science:

  • Cell biology
  • Immunology
  • Molecular biology

Background:

  • The Hippo pathway is a key regulator of organ size, responding to environmental cues like nutrient availability, cell density, and substrate stiffness.
  • Interferon production is crucial for antiviral defense, primarily controlled by the TBK1 kinase.

Purpose of the Study:

  • To investigate the role of the Hippo pathway in antiviral defense.
  • To elucidate the mechanism by which the Hippo pathway influences interferon production.

Main Methods:

  • Western blotting
  • Quantitative PCR
  • Immunofluorescence microscopy

Main Results:

  • The Hippo pathway was found to regulate antiviral responses.

Related Experiment Videos

  • Hippo pathway signaling modulates TBK1 activity.
  • This modulation affects the production of interferons.

    • Conclusions:

    • The Hippo pathway plays a novel role in innate antiviral immunity.
    • The Hippo pathway integrates environmental sensing with immune responses through TBK1-mediated interferon control.