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The Vietnamese pig as a translational animal model to evaluate tissue engineered heart valves: promising early
Michele Gallo1, Helen Poser2, Tommaso Bottio1
1Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua - Italy.
The International Journal of Artificial Organs
|April 1, 2017
Abstract:
Several animal models are currently used for the surgical implantation of either biologic or biopolymeric scaffolds in order to provide in vivo assessment of tissue-engineered heart valves. The Vietnamese pig (VP) is herein proposed as a suitable recipient to test the function of novel bioengineered valve substitutes, in the reconstruction of the right ventricular outflow tract (RVOT). This review aims to provide a complete and exhaustive panel of physiological parameters and methodological information for preclinical studies of tissue-engineered heart valves in the VP animal model.