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Related Experiment Videos

A pilot study on the applicability of thromboelastometry in detecting brain tumour-induced hypercoagulation.

Erik Jansohn1, Johan Bengzon2, Thomas Kander1,3

  • 1a Department of Anaesthesia and Intensive Care , Institution of Clinical Science Lund, Medical Faculty, Lund University , Lund , Sweden.

Scandinavian Journal of Clinical and Laboratory Investigation
|April 1, 2017
PubMed
Summary

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This summary is machine-generated.

Rotational thromboelastometry (ROTEM) can detect procoagulant and fibrinolytic activity in brain tumor tissue. Glioma tumors showed the strongest hypercoagulative response in this in vitro study.

Area of Science:

  • Neuro-oncology
  • Hemostasis and Thrombosis
  • Surgical Pathology

Background:

  • Patients with intracranial tumors face elevated venous thromboembolism risk post-neurosurgery.
  • Tumor-derived procoagulant substances are implicated in this increased risk.

Purpose of the Study:

  • To evaluate if rotational thromboelastometry (ROTEM) can quantify the procoagulative activity of brain tumor tissue.
  • To investigate the hemostatic and fibrinolytic effects of intracranial tumor extracts.

Main Methods:

  • In vitro analysis of 21 patient-derived intracranial tumor tissue samples.
  • Tumor tissue was used to spike patient's whole blood for ROTEM analysis.
  • ROTEM assays were performed with various activating reagents to assess clotting dynamics.
Keywords:
Gliomaneurosurgerypoint-of-care testingproteins and enzymessurgerythrombelastographytumor markers

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Main Results:

  • ROTEM detected significant hypercoagulative responses (decreased clotting time) and strong fibrinolytic activity (increased maximum lysis) in tumor-spiked blood.
  • Glioma tumors exhibited the most pronounced hypercoagulative effect.
  • A prolonged clot formation time indicated impaired initial clot propagation.

Conclusions:

  • Intracranial tumor tissue possesses both procoagulant and fibrinolytic properties detectable by ROTEM.
  • ROTEM shows potential for assessing the hemostatic impact of brain tumors.
  • Further research is needed to validate these findings for clinical risk prediction of thrombosis.