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Canakinumab for the treatment of familial Mediterranean fever

Huri Ozdogan1, Serdal Ugurlu1

  • 1a Division of Rheumatology, Department of Internal Medicine , Cerrahpasa Medical Faculty, Istanbul University , Fatih , Istanbul , Turkey.

Expert Review of Clinical Immunology
|April 1, 2017
PubMed
Abstract

Insights

Familial Mediterranean fever (FMF) is an autoinflammatory syndrome. Canakinumab, an anti-interleukin-1β drug, is a new FDA-approved therapy for FMF patients resistant to colchicine.

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Familial Mediterranean fever (FMF) is the most common hereditary autoinflammatory syndrome.
  • Characterized by recurrent fever and serositis, FMF can lead to AA amyloidosis if untreated.
  • MEFV gene mutations affecting IL-1β regulation cause FMF.

Purpose of the Study:

  • To review the efficacy and importance of canakinumab for FMF treatment.
  • To highlight canakinumab as an alternative therapy for colchicine-resistant FMF.

Main Methods:

  • Review of accumulating data on anti-IL-1 drugs in FMF.
  • Focus on canakinumab, a fully human anti-IL-1β antibody.

Main Results:

  • Anti-IL-1 drugs demonstrate effectiveness in colchicine-resistant FMF.
  • Canakinumab improves quality of life in FMF patients.

Conclusions:

  • Canakinumab is the first FDA-approved therapy for FMF.
  • Canakinumab represents a significant alternative treatment for FMF.
Keywords:
Anti IL-1 drugsCanakinumabIL-1βcolchicine-resistant familial Mediterranean feverfamilial Mediterranean feverhereditary periodic fever syndromes

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