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Progressive multifocal leukoencephalopathy due to John Cunningham (JC) virus following allogeneic haematopoietic cell
Wilson Lam1, Zeyad Al-Shaibani1, Deepali Kumar2
1Allogeneic Blood and Marrow Transplant Program, Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Abstract:
Progressive multifocal leukoencephalopathy (PML) is an uncommon infectious complication post allogeneic stem cell transplant. We present a case report of a patient developing this complication with a review of the current literature. It also describes the first use of artesunate in a clinical case of PML with no beneficial effect.
Insights
Progressive multifocal leukoencephalopathy (PML) is a rare complication after stem cell transplants. This case report details a patient with PML and reviews literature, noting artesunate
Area of Science:
- Neurology
- Infectious Diseases
- Hematology
Background:
- Allogeneic stem cell transplantation (SCT) can lead to opportunistic infections.
- Progressive multifocal leukoencephalopathy (PML) is a rare but serious complication post-SCT.
Observation:
- A case of a patient developing PML following allogeneic SCT is presented.
- The clinical course and diagnostic findings of the patient are detailed.
Findings:
- Literature review on PML post-SCT is provided.
- Artesunate was administered to the patient with PML, but showed no beneficial effect.
Implications:
- This case highlights the challenges in managing PML in SCT recipients.
- Further research is needed to identify effective treatments for PML post-SCT.