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Related Experiment Videos

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles.

Ningquan Wang1, Ruxiu Liu1, A Fatih Sarioglu2

  • 1School of Electrical and Computer Engineering, Georgia Institute of Technology.

Journal of Visualized Experiments : Jove
|April 1, 2017
PubMed
Summary
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This study introduces Microfluidic CODES, an electronic sensing technology that electronically detects and sizes cells in microfluidic channels. This innovation enables low-cost, portable lab-on-a-chip devices for point-of-care diagnostics.

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Electronic Sensing

Background:

  • Microfluidic devices fractionate biological samples using force fields.
  • Current methods require complex, costly microscopic analysis for readouts.
  • This limits portability and accessibility for point-of-care applications.

Purpose of the Study:

  • To develop an integrated electronic sensing technology for multiplexed particle detection in microfluidics.
  • To overcome limitations of external instrumentation in microfluidic assays.
  • To enable low-cost, portable lab-on-a-chip devices.

Main Methods:

  • Developed Microfluidic CODES (Code Division Multiple Access) technology.
  • Combined Resistive Pulse Sensing with Code Division Multiple Access.

Related Experiment Videos

  • Compressed 2D spatial information into a 1D electrical signal for analysis.

    • Main Results:

    • Demonstrated detection and sizing of cultured cancer cells in microfluidic channels.
    • Accurately analyzed dense cell populations electronically.
    • Validated results using high-speed microscopy.

    Conclusions:

    • Microfluidic CODES enables electronic detection without external instruments.
    • The technology facilitates integrated, low-cost lab-on-a-chip devices.
    • Potential for widespread use in point-of-care testing.