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Correction: Programmable RNA microstructures for coordinated delivery of siRNAs.

Jaimie Marie Stewart1, Mathias Viard, Hari K K Subramanian

  • 1Department of Bioengineering, University of California, Riverside, Riverside, CA 92521, USA.

Nanoscale
|April 1, 2017
PubMed
Summary

This correction clarifies details regarding programmable RNA microstructures designed for the coordinated delivery of small interfering RNAs (siRNAs). The updated information ensures accuracy in the reporting of these advanced nucleic acid delivery systems.

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Molecular Biology

Background:

  • RNA interference (RNAi) is a powerful gene silencing mechanism.
  • Effective delivery of small interfering RNAs (siRNAs) remains a challenge in therapeutic applications.
  • Programmable nanostructures offer potential for targeted and controlled siRNA delivery.

Purpose of the Study:

  • To correct and provide precise details on programmable RNA microstructures.
  • To ensure accurate representation of the siRNA delivery system's design and function.
  • To maintain the integrity and reproducibility of the original research findings.

Main Methods:

  • Review and verification of experimental data and procedures.
  • Clarification of fabrication techniques for RNA microstructures.
  • Refinement of characterization methods for the nanostructures.

Main Results:

  • Specific adjustments to the reported dimensions and properties of the RNA microstructures.
  • Correction of parameters related to siRNA loading and release kinetics.
  • Updated information on the stability and integrity of the microstructures.

Conclusions:

  • The corrected information enhances the understanding of programmable RNA microstructures for siRNA delivery.
  • Accurate data is crucial for the advancement of RNA-based therapeutics.
  • This correction ensures the reliability of findings for future research and development.