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Direct Catalytic Asymmetric Reductive Amination of Aliphatic Ketones Utilizing Diphenylmethanamine as Coupling
Haizhou Huang1, Yunfei Zhao1, Yang Yang1
1College of Chemistry and Pharmacy, Northwest A&F University , 22 Xinong Road, Yangling, Shaanxi 712100, PR China.
Organic Letters
|April 1, 2017
Abstract:
The highly efficient direct catalytic reductive amination of ketones with diphenylmethanamine catalyzed by iridium-phosphoramidite complexes is described. As an effective coupling partner, diphenylmethanamine is suitable for a wide range of ketones to provide chiral amines in high yields and enantioselectivity. The chiral monodentate phosphoramidite ligands are tunable and competent to accommodate substrates with different structures.