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Three-Dimensional Printed Modeling of Diffuse Low-Grade Gliomas and Associated White Matter Tract Anatomy
Jayesh P Thawani1,2, Nickpreet Singh1,3, Jared M Pisapia1,3
1Department of Neurosurgery, Univer-sity of Pennsylvania, Philadelphia, Pennsylvania.
Background:
Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain.
Objective:
To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy.
Methods:
Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques.
Results:
This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution.
Conclusion:
Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.