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Association between single nucleotide polymorphisms in AKT1 and the risk of prostate cancer in the Chinese Han

J M Liu1, S H Cheng2, C Xia3

  • 1Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology) West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Genetics and Molecular Research : GMR
|April 1, 2017
PubMed

Insights

Genetic variants in AKT1 may influence cancer development. A specific AKT1 gene variant (rs3730358 CT genotype) was linked to a reduced risk of prostate cancer in the Chinese Han population.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • The AKT1 gene (v-akt murine thymoma viral oncogene homolog 1) regulates cell survival and apoptosis, processes implicated in cancer pathogenesis.
  • The specific role of genetic variations in AKT1 concerning prostate cancer risk remains largely unexplored.

Purpose of the Study:

  • To investigate the association between three common AKT1 gene polymorphisms (rs1130214, rs3730358, and rs2494732) and the risk of developing prostate cancer.
  • To analyze these associations within the Chinese Han population.

Main Methods:

  • Genotyping of AKT1 polymorphisms (rs1130214, rs3730358, rs2494732) using Sequenom MassARRAY & iPLEX technology.
  • Case-control study design involving 493 prostate cancer patients and 309 healthy controls from the Chinese Han population.

Main Results:

  • The CT genotype of the rs3730358 polymorphism in AKT1 showed a significant association with a decreased risk of prostate cancer (OR = 0.617, P = 0.037) compared to the CC genotype.
  • No significant associations were found for allele frequencies of rs3730358 or the other two polymorphisms (rs1130214, rs2494732).
  • Haplotype analysis did not reveal any significant differences.

Conclusions:

  • The variant genotype CT of AKT1 rs3730358 is associated with a reduced risk of prostate cancer in the Chinese Han population.
  • This specific AKT1 polymorphism may play a role in prostate cancer development, warranting further investigation.

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