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Related Experiment Videos

Irritability in ADHD: Associations with depression liability.

Olga Eyre1, Kate Langley2, Argyris Stringaris3

  • 1MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Wales, UK.

Journal of Affective Disorders
|April 1, 2017
PubMed
Summary

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This summary is machine-generated.

Irritability and Disruptive Mood Dysregulation Disorder (DMDD) are common in children with Attention Deficit Hyperactivity Disorder (ADHD). These symptoms are associated with increased risk for anxiety, depression, and a family history of depression.

Area of Science:

  • Child and Adolescent Psychiatry
  • Neurodevelopmental Disorders
  • Mood Disorders

Background:

  • Irritability is frequently observed in Attention Deficit Hyperactivity Disorder (ADHD).
  • The association between irritability, Disruptive Mood Dysregulation Disorder (DMDD), and depression risk in ADHD remains under-explored.
  • Disruptive Mood Dysregulation Disorder (DMDD) is a new diagnostic category in DSM-5, often conceptualized within mood disorders.

Purpose of the Study:

  • To determine the prevalence of irritability and DMDD in a clinical sample of children with ADHD.
  • To investigate the relationship between irritability and DMDD with anxiety, depression, and family history of depression in children with ADHD.

Main Methods:

  • A clinical sample of 696 children diagnosed with ADHD was recruited from UK clinics.
Keywords:
ADHDDMDDDepressionIrritability

Related Experiment Videos

  • Parents completed diagnostic interviews and questionnaires assessing child's symptoms (irritability, anxiety, depression), DMDD, and family history of depression.
  • Parental depression was also assessed to understand its influence.

    • Main Results:

    • High prevalence of irritability (91% endorsing at least one symptom) and DMDD (31% 3-month prevalence) was found in the ADHD sample.
    • Children with elevated irritability or DMDD showed higher rates of comorbid anxiety, depression, and a positive family history of depression.
    • These findings suggest irritability and DMDD are linked to depression liability in youth with ADHD.

    Conclusions:

    • Irritability and DMDD are prevalent in children with ADHD and are associated with indicators of depression risk.
    • Further longitudinal research is recommended to clarify the developmental trajectory of irritability and depression in this population.
    • Clinical attention to irritability and DMDD may be important for identifying youth with ADHD at higher risk for mood disorders.