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A different scintigraphic approach to evaluate the glomerular filtration rate
T Haciosmanoglu1, A O Karacalioglu1, T Eyileten2
1Department of Nuclear Medicine, Gulhane Training and Research Hospital, Etlik-Ankara, Turkey.
Revista Espanola De Medicina Nuclear E Imagen Molecular
|April 2, 2017
Summary
A new camera-based method accurately measures renal glomerular filtration rate (GFR). This approach, using Technetium 99m diethylene-triamine-pentaacetic acid (99mTc-DTPA), offers a practical alternative to existing GFR measurement techniques.
Area of Science:
- Nuclear Medicine
- Renal Physiology
- Medical Imaging
Background:
- Existing nuclear medicine techniques for measuring renal glomerular filtration rate (GFR) present practical limitations and accuracy issues.
- There is a need for improved, routine-use methods for GFR assessment.
Purpose of the Study:
- To develop and validate a novel camera-based approach for measuring GFR.
- To compare the new method's results against established measured GFR (mGFR) and estimated GFR (eGFR) values.
Main Methods:
- A cohort of 34 patients received an injection of approximately 74MBq (2mCi) of 99mTc-DTPA over 5 minutes.
- A simple dilution principle-based formula was employed to calculate GFR, termed ScinGFR.
- ScinGFR results were compared with creatinine clearance and other established eGFR equations.
Main Results:
- The developed formula (ScinGFR) yielded mGFR results comparable to creatinine clearance within a narrower range.
- A significant difference was observed between ScinGFR and the Cockcroft-Gault equation (p=0.031).
- However, ScinGFR showed no significant difference when compared to other equations, excluding Cockcroft-Gault (p=0.164).
Conclusions:
- A straightforward formula, incorporating extracellular fluid volume, effectively predicts renal split and global kidney function.
- The new camera-based method demonstrates good correlation with existing GFR formulas, despite minor discrepancies.
- This technique offers a promising, practical alternative for routine GFR measurement.