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A New Method for Inducing a Depression-Like Behavior in Rats

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Published on: February 22, 2018

Trajectories of Depressive Symptoms Among Web-Based Health Risk Assessment Participants.

Richard Bedrosian¹, Matt Hawrilenko², Heather Cole-Lewis¹

¹Johnson & Johnson Health & Wellness Solutions, Johnson & Johnson, New Brunswick, NJ, United States.

Journal of Medical Internet Research

|April 2, 2017

Summary

Health risk assessments reveal distinct depressive symptom trajectories in over 22,000 individuals. One in five with subthreshold symptoms deteriorated, highlighting the need for targeted interventions and further research into predictive factors.

Keywords:

depression health risk appraisal health surveys prevention prodromal symptoms

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Area of Science:

Psychiatry and Mental Health
Health Services Research
Longitudinal Data Analysis

Background:

Millions annually undergo health risk assessments (HRAs) that screen for depressive symptoms.
HRA data offer a unique opportunity to study longitudinal trends in depressive symptomatology.
Previous research has examined these trends in other populations.

Purpose of the Study:

To identify longitudinal depressive symptom trajectories within HRA populations.
To determine if modifiable health risks predict these trajectories.
To inform population health management strategies for HRA participants.

Main Methods:

Utilized growth mixture modeling (GMM) on data from 22,963 participants in a web-based HRA.
Analyzed longitudinal trends in depressive symptomatology.
Assessed modifiable health risks, stress, sleep, and quality of life.

Main Results:

Identified five distinct depressive symptom trajectories: minimal, low risk, deteriorating, chronic, and remitting.
1 in 5 participants with subthreshold symptoms showed deterioration.
Predictors varied by trajectory, with factors like age, sex, sleep quality, and treatment influencing outcomes.

Conclusions:

Longitudinal depressive trajectories in HRA populations mirror those found in other studies.
Identified key predictors warranting further investigation for targeted interventions.
Emphasized the need for proactive population health management for individuals at risk of depressive symptom deterioration.