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Methods to decrease variability in histological scoring in placentas from a cohort of preterm infants.

Jennifer K Straughen1, Dawn P Misra2, Linda M Ernst3,4

  • 1Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA.

BMJ Open
|April 2, 2017
PubMed
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This summary is machine-generated.

Histological assessment of placental inflammation is challenging. Using digitized regions of interest (ROIs) significantly improved pathologist agreement and reliability in scoring neutrophil infiltrates, enhancing diagnostic accuracy.

Area of Science:

  • Pathology
  • Histology
  • Obstetrics

Background:

  • Semiquantitative assessment of placental acute inflammation is difficult due to variability in neutrophil infiltrates.
  • Pathologist scoring of placental histology slides lacks consistent reliability.

Purpose of the Study:

  • To reduce variability in pathologists' scoring of placental neutrophil infiltrates.
  • To determine if using 'regions of interest' (ROIs) improves scoring reliability.

Main Methods:

  • Histological placental slides from 56 women were analyzed.
  • Regions of interest (ROIs) were scored semiquantitatively (0-4) for neutrophils by at least two raters.
  • Interrater agreement was assessed using intraclass correlation coefficient (ICC) and log-linear regression; predictive validity was assessed against amniotic fluid protein profiles.
Keywords:
HISTOPATHOLOGYPERINATOLOGYSTATISTICS & RESEARCH METHODSneutrophils

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Main Results:

  • Excellent interrater agreement (ICC) was achieved for neutrophil scores within ROIs.
  • Log-linear analyses showed positive associations in scoring, even with minor disagreements.
  • Strong predictive validity was observed when comparing pathologist scores with amniotic fluid protein profiles.

Conclusions:

  • Digitized ROIs improve the feasibility, reliability, and validity of semiquantitative neutrophil scoring in placental histology.
  • This method enhances diagnostic consistency for placental inflammation assessment.