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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Magnetic resonance imaging for characterizing myocardial diseases

Maythem Saeed1, Hui Liu2, Chang-Hong Liang2

  • 1Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, 185 Berry Street, Suite 350, Campus Box 0946, San Francisco, CA, 94107-5705, USA. msaeed@UCSF.edu.

The International Journal of Cardiovascular Imaging
|April 2, 2017
PubMed

Insights

Cardiomyopathy, diseases of the heart muscle, are diagnosed using cardiac magnetic resonance imaging (MRI). MRI reveals myocardial structure, function, and fibrosis, aiding in diagnosis and treatment monitoring for various heart muscle diseases.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Cardiology

Background:

  • Cardiomyopathy encompasses diverse heart muscle diseases with varying causes, structures, and treatments.
  • Accurate diagnosis and characterization are crucial for effective management.

Purpose of the Study:

  • To review key cardiac magnetic resonance imaging (MRI) features of different cardiomyopathies.
  • To highlight MRI's role in assessing myocardial structure, function, perfusion, and viability.

Main Methods:

  • Standard and contrast-enhanced cardiac MRI sequences for evaluating left ventricular (LV) mass, volumes, and function.
  • Advanced techniques including myocardial strain analysis, tissue mapping (T1, T2, T2*), and extracellular volume (ECV) estimation.

Main Results:

  • Cardiac MRI visualizes infarct patterns, myocardial inflammation, and diffuse fibrosis, differentiating various cardiomyopathies.
  • Imaging findings correlate with disease etiology, predict functional recovery, and guide therapeutic monitoring.

Conclusions:

  • Cardiac MRI is indispensable for diagnosing and monitoring myocardial diseases.
  • Advanced MRI techniques offer insights into etiology and disease progression, with potential for integrated PET/MRI systems.

Keywords:
CardiomyopathyHeart musclesMagnetic resonance imaging

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