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Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue
Caroline Gluck1,2, Yi-An Ko1,3, Katalin Susztak4,5
1Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, 415 Clinical Research Building, Philadelphia, PA, 19104, USA.
Purpose Of Review:
Precision medicine approaches, that tailor medications to specific individuals has made paradigm-shifting improvements for patients with certain cancer types.
Recent Findings:
Such approaches, however, have not been implemented for patients with diabetic kidney disease. Precision medicine could offer new avenues for novel diagnostic, prognostic and targeted therapeutics development. Genetic studies associated with multiscalar omics datasets from tissue and cell types of interest of well-characterized cohorts are needed to change the current paradigm. In this review, we will discuss precision medicine approaches that the nephrology community can take to analyze tissue samples to develop new therapeutics for patients with diabetic kidney disease.
Insights
Precision medicine, tailoring treatments to individuals, has advanced cancer care but not diabetic kidney disease. Future research requires genetic and omics data to develop targeted therapies for diabetic kidney disease.
Area of Science:
- Nephrology
- Genomics
- Precision Medicine
Background:
- Precision medicine has revolutionized cancer treatment by tailoring therapies to individual patients.
- Diabetic kidney disease (DKD) currently lacks personalized treatment strategies.
- There is a significant unmet need for novel diagnostic, prognostic, and therapeutic approaches in DKD.
Purpose of the Study:
- To review precision medicine strategies applicable to diabetic kidney disease.
- To explore the potential of genetic and multi-omics data in advancing DKD research.
- To discuss how the nephrology community can leverage tissue analysis for developing new DKD therapeutics.
Main Methods:
- Review of current literature on precision medicine in oncology and nephrology.
- Analysis of the role of genetic studies and multi-scalar omics datasets.
- Discussion of tissue sample analysis techniques for DKD.
Main Results:
- Precision medicine has not yet been widely implemented in diabetic kidney disease.
- Genetic and omics data hold significant potential for DKD biomarker discovery and therapeutic development.
- Tissue analysis offers a pathway to understanding DKD heterogeneity.
Conclusions:
- Precision medicine offers a promising paradigm shift for diabetic kidney disease management.
- Integration of genetic and omics data is crucial for developing targeted DKD therapies.
- The nephrology community must embrace advanced analytical approaches for DKD research and treatment.