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Related Experiment Videos

Restoring function in major depressive disorder: A systematic review.

David V Sheehan1, Kazuyuki Nakagome2, Yuko Asami3

  • 1University of South Florida College of Medicine, Tampa, FL, USA.

Journal of Affective Disorders
|April 2, 2017
PubMed
Summary
This summary is machine-generated.

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Functional impairment in major depressive disorder (MDD) often persists despite symptom improvement. Early treatment response predicts functional gains, suggesting routine monitoring can minimize residual deficits.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Major depressive disorder (MDD) causes significant disability and economic burden.
  • Functional impairment in MDD often lags behind symptom improvement, increasing relapse risk.

Purpose of the Study:

  • To review functional outcomes in major depressive disorder treatment.
  • To identify predictors of functional improvement in MDD.

Main Methods:

  • A literature search identified 35 controlled studies of MDD treatment (1995-2016).
  • Studies included adult, acute-phase, nonrecurrent MDD trials measuring functional outcomes at baseline and endpoint.

Main Results:

  • Antidepressant treatments significantly improved functional outcomes.
Keywords:
Functional ImpairmentFunctional RemissionMajor Depressive DisorderQuality of LifeSocial ImpairmentWork Performance

Related Experiment Videos

  • Early symptomatic response predicted functional improvement, unlike baseline disease severity.
  • The Sheehan Disability Scale was the most frequent functional assessment tool.

    • Conclusions:

    • A disconnect exists between symptomatic and functional recovery in MDD, indicating an unmet clinical need.
    • Routine monitoring of both symptoms and functionality may reduce residual functional impairments.