Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute bone changes after lower limb amputation resulting from traumatic injury.

D A Bemben1, V D Sherk2, W J J Ertl3

  • 1Bone Density Research Laboratory, Department of Health and Exercise Science, University of Oklahoma, 1401 Asp Avenue, Norman, OK, 73019, USA. dbemben@ou.edu.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|April 3, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating MiR-21 expression is upregulated after 30 days of head-down tilt bed rest.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Fat Mass Is Negatively Associated with Muscle Strength and Jump Test Performance.

The Journal of frailty & aging·2020
Same author

Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment.

Bone·2020
Same author

Is regular exercise an effective strategy for weight loss maintenance?

Physiology & behavior·2018
Same author

Relationship between muscle performance and DXA-derived bone parameters in community-dwelling older adults.

Journal of musculoskeletal & neuronal interactions·2017
Same author

The acute muscular effects of cycling with and without different degrees of blood flow restriction.

Acta physiologica Hungarica·2015

Lower limb amputees experience significant bone loss in the first year of prosthesis use. Interventions are needed early post-amputation to prevent bone density and strength decline.

Area of Science:

  • Orthopedics
  • Bone Metabolism
  • Prosthetics

Background:

  • Lower limb amputation leads to significant bone density deficits.
  • The progression of bone quality changes post-amputation is not well understood.

Purpose of the Study:

  • To quantify bone quality changes in the amputated limb during early stages post-amputation.

Main Methods:

  • Assessed bone mineral density (BMD), volumetric BMD (vBMD), and bone strength (SSI) in eight unilateral amputees.
  • Measurements were taken pre-ambulatory and at 6 and 12 months post-prosthesis fitting.
  • Bone turnover markers were also analyzed.

Main Results:

  • Hip areal BMD decreased 11-15% and persisted for 12 months.
Keywords:
Bone densityBone geometryBone remodelingProsthesisTrauma

Related Experiment Videos

  • Amputated bone showed significant decreases in BMC, vBMD, and SSI by 6 months, maintained at 12 months.
  • Increased cortical porosity and altered bone turnover markers were observed.

    • Conclusions:

    • Rapid bone loss occurs early after amputation and does not recover within the first year.
    • Early post-amputation is a critical window for interventions to mitigate bone loss.