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Updated: Aug 12, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
10:37

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SOX5 promotes epithelial-mesenchymal transition in osteosarcoma via regulation of Snail

Daiyang Zhang1, Shiqing Liu

  • 1Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, 430060, China.

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
|April 3, 2017
PubMed
Abstract

Insights

SOX5 is upregulated in osteosarcoma (OS) and promotes cancer cell migration and invasion by regulating epithelial-mesenchymal transition (EMT). SOX5 is a potential therapeutic target for OS treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • SOX5 is implicated in various cancers.
  • Its role in osteosarcoma (OS) requires further investigation.

Purpose of the Study:

  • To investigate the expression and mechanism of SOX5 in osteosarcoma.
  • To determine if SOX5 is a potential therapeutic target for OS.

Main Methods:

  • SOX5 mRNA and protein levels were analyzed in OS tissues and cell lines.
  • Gain- and loss-of-function studies were performed using shRNA and recombinant plasmids.
  • Cell migration, invasion, and epithelial-mesenchymal transition (EMT) markers were assessed.

Main Results:

  • SOX5 expression was significantly upregulated in OS tissues and cell lines.
  • SOX5 overexpression enhanced OS cell migration and invasion.
  • SOX5 promoted EMT by regulating Snail expression.

Conclusions:

  • SOX5 acts as a novel regulator of EMT in osteosarcoma.
  • SOX5 represents a potential therapeutic target for osteosarcoma.

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