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Updated: Jul 3, 2026

Oscillation and Reaction Board Techniques for Estimating Inertial Properties of a Below-knee Prosthesis
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Published on: May 8, 2014

Identification of Biokinetic Models Using the Concept of Extents

Alma Mašić1, Sriniketh Srinivasan2, Julien Billeter2

  • 1Eawag: Swiss Federal Institute of Aquatic Science and Technology , Überlandstrasse 133, CH-8600 Dübendorf, Switzerland.

Environmental Science & Technology
|April 4, 2017
PubMed

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Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
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Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
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Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
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