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Safety of Treatments for ADHD in Adults: Pairwise and Network Meta-Analyses
Danielly Chierrito de Oliveira1, Patricia Guerrero de Sousa1, Camila Borges Dos Reis1
11 Universidade Estadual do Oeste do Paraná, Cascavel, Brazil.
Objective:
The aim of the study was to analyze evidence comparing the profile of drugs used to treat ADHD in adult patients.
Method:
Systematic searches were conducted in electronic databases. Randomized, double-blind, parallel controlled trials that evaluated the safety of drugs in ADHD were included. The statistical analyses were conducted by pairwise meta-analyses and mixed treatment comparison (MTC).
Results:
Ten ( n = 3006) trials were included in the analyses. We observed statistical differences for the following outcomes: decreased appetite between atomoxetine and placebo (odds ratio [OR] = 0.15, 95% credibility interval [CrI] = [0.05, 0.38]) and extended-release mixed amphetamine salts and placebo (OR = 0.06, 95% CrI = [0.00, 0.51]); insomnia between atomoxetine and placebo (OR = 0.48, 95% CrI = [0.27, 0.88]) and extended-release mixed amphetamine salts and placebo (OR = 0.23, 95% CrI = [0.06, 0.76]); sleepiness between atomoxetine and methylphenidate OROS (OR = 0.24, 95% CrI = [0.06, 0.97]); and decreased libido between atomoxetine and placebo (OR = 0.28, 95% CrI = [0.08, 0.90]).
Conclusion:
It was possible to generate evidence about the safety profile of different ADHD drugs.