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Related Experiment Videos

A path to precision in the ICU.

David M Maslove1,2,3, Francois Lamontagne4,5,6, John C Marshall7,8,9

  • 1Department of Critical Care Medicine, Queen's University, Kingston, ON, Canada. david.maslove@queensu.ca.

Critical Care (London, England)
|April 4, 2017
PubMed
Summary

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Precision medicine offers a tailored approach to critical care, addressing patient heterogeneity in intensive care units (ICUs). Novel trial designs and data analytics are key to advancing precision critical care.

Area of Science:

  • Biomedicine
  • Critical Care Medicine
  • Translational Research

Background:

  • Precision medicine is a new paradigm in biomedicine.
  • Critical illness syndromes like sepsis and ARDS exhibit significant patient heterogeneity.
  • Current one-size-fits-all ICU therapies yield variable results, highlighting the need for precision.

Purpose of the Study:

  • To explore the adoption of precision medicine in the ICU.
  • To identify and address challenges in implementing precision critical care.
  • To propose concrete approaches for advancing precision critical care.

Main Methods:

  • Adapting conventional clinical trials with novel designs (registry randomized controlled trials, platform trials).
  • Leveraging ICU's data-rich environment for complex physiologic signatures.
Keywords:
Biomedical informaticsClinical trialsCritical careGenomicsIntensive care unitPersonalized medicinePrecision healthPrecision medicine

Related Experiment Videos

  • Utilizing advanced computing infrastructure and informatics methods.

    • Main Results:

    • Novel trial designs can accommodate physiologic heterogeneity in critical illness.
    • ICU data and "omics" technologies can fuel precision research.
    • Computing and informatics are crucial for precision medicine in the ICU.

    Conclusions:

    • Transitioning to precision critical care requires addressing challenges incrementally.
    • Collaboration with data scientists is essential.
    • Proof-of-concept studies can demonstrate the potential of precision critical care.