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Related Experiment Videos

Pathogen-derived extracellular vesicles coordinate social behaviour and host manipulation.

Yifat Ofir-Birin1, Meta Heidenreich1, Neta Regev-Rudzki1

  • 1Faculty of Biochemistry, Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

Seminars in Cell & Developmental Biology
|April 4, 2017
PubMed
Summary

Pathogens use extracellular vesicles (EVs) for cell-cell communication, influencing disease progression and host responses. Understanding this communication is key to developing new therapies against infectious diseases.

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Area of Science:

  • Microbiology
  • Immunology
  • Cell Biology

Background:

  • Infectious diseases pose a significant global health challenge, particularly for children.
  • Pathogen-host interactions are complex, involving intricate cell-cell communication mechanisms.
  • Pathogens utilize secreted vesicles for intercellular communication, transferring molecules that alter recipient cell functions.

Purpose of the Study:

  • To review the role of extracellular vesicles (EVs) in pathogen social interactions and communication.
  • To highlight how pathogens employ EVs to modulate host immune and non-immune responses.
  • To emphasize the therapeutic potential of understanding pathogen-host communication via EVs.

Main Methods:

  • Literature review focusing on extracellular vesicles (EVs) in infectious diseases.
Keywords:
Cell–cell communicationExtracellular vesiclesInfectious diseasesMicrobiology

Related Experiment Videos

  • Analysis of mechanisms by which pathogens use EVs for communication.
  • Examination of EV-mediated manipulation of host responses.

    • Main Results:

    • Pathogens use EVs for intra- and inter-species communication, coordinating virulence and population density.
    • EVs facilitate the transfer of biologically active molecules, inducing phenotypic changes in host cells.
    • Pathogens leverage EVs to suppress host immunity and promote their survival.

    Conclusions:

    • Extracellular vesicles play a critical role in the social behavior of pathogens.
    • Understanding EV-mediated communication is crucial for deciphering pathogen-host interactions.
    • Targeting EV communication pathways offers promising therapeutic strategies against infectious agents.