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Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression
1Head and Neck Cancer Research Division, Department of Otolaryngology/Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.
Current Genomics
|April 4, 2017
Summary
Natural compounds offer promising anticancer therapeutics by targeting cancer's epigenetic hallmarks. These bioactive ingredients modulate gene expression and DNA repair, advancing novel cancer treatment strategies.
Area of Science:
- Oncology
- Epigenetics
- Pharmacology
Background:
- Cancer development is characterized by genetic and epigenetic alterations.
- Natural compounds from diverse sources are emerging as potent anticancer agents.
- These compounds can influence epigenetic mechanisms and DNA repair pathways.
Purpose of the Study:
- To review recent advancements in natural compounds targeting epigenetic regulators in cancer therapy.
- To highlight the potential of natural compounds in modulating gene transcription for anticancer drug development.
Main Methods:
- Literature review of preclinical studies on natural compounds and epigenetic targets.
- Analysis of in vitro and in vivo data on the efficacy of natural compounds.
- Focus on compounds affecting epigenetic regulators and gene transcription modulators.
Main Results:
- Natural compounds demonstrate significant potential in targeting key epigenetic alterations in cancer.
- Evidence supports the role of natural compounds in modulating gene expression and DNA repair.
- Preclinical studies show promising results for novel anticancer therapeutics derived from natural sources.
Conclusions:
- Natural compounds represent a promising avenue for developing novel anticancer therapeutics.
- Targeting epigenetic regulators with natural compounds offers a new strategy for cancer treatment.
- Further research into natural compounds could lead to significant breakthroughs in oncology.