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Neural stem cell heterogeneity through time and space in the ventricular-subventricular zone
Gabrielle Rushing1, Rebecca A Ihrie2
1Program in Neuroscience, Vanderbilt University, Nashville, TN 37232, USA.
Frontiers in Biology
|April 4, 2017
Summary
Neural stem cells (NSCs) are a heterogeneous pool in the brain. Understanding their identity and fate is key for developing therapies for brain injury and disease.
Area of Science:
- Neuroscience
- Stem Cell Biology
- Developmental Biology
Background:
- Neural stem cells (NSCs) are a heterogeneous population in both embryonic and adult brains.
- Adult NSCs offer potential for neuronal and glial replacement after injury or disease.
- Understanding NSC programming and fate determination is crucial for therapeutic applications.
Purpose of the Study:
- To review the identification, classification, and characterization of NSCs in the ventricular-subventricular zone (V-SVZ).
- To highlight recent advances in understanding NSC heterogeneity and fate determination.
Main Methods:
- Literature search of PubMed using keywords: "ventricular-subventricular zone," "neural stem cell," "heterogeneity," "identity," and "single cell."
- Focus on recent single-cell analyses of NSCs within their niche.
Main Results:
- Discussion of over 20 articles on V-SVZ NSC heterogeneity and over 25 on fate determinants.
- Focus on 8 recent single-cell analyses (flow cytometry, RNA-seq).
- Inclusion of a chart detailing markers for over 60 NSC lineage manuscripts.
Conclusions:
- NSC heterogeneity and fate decisions are active research areas.
- Findings from mouse models are discussed alongside human and other mammalian data.
- Exploration of how embryonic NSC heterogeneity impacts adult brain properties and potential therapeutic redirection after injury.