Related Experiment Video

Updated: Aug 12, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

Frequency of Hepatitis C in hospitalized patients with chronic kidney disease

Salman Tahir Shafi1, Muhammad Zaigham Hassan2, Mohammed Saleem3

  • 1Dr. Salman Tahir Shafi, Associate Professor of Nephrology, Department of Nephrology, Sharif Medical and Dental College, Sharif Medical City Road JatiUmra, Lahore, Pakistan.

Pakistan Journal of Medical Sciences
|April 4, 2017
PubMed

Insights

A significant number of hospitalized patients with chronic kidney disease (CKD) in Pakistan have Hepatitis C. This highlights the need for strict infection control measures in nephrology wards to prevent further spread of the virus.

Area of Science:

  • Nephrology
  • Hepatology
  • Infectious Diseases

Background:

  • Chronic kidney disease (CKD) and Hepatitis C are significant global health concerns, particularly prevalent in Pakistan.
  • Limited data exists on Hepatitis C prevalence among non-dialysis CKD patients.

Purpose of the Study:

  • To determine the frequency of Hepatitis C infection in hospitalized CKD patients at a tertiary care center in Pakistan.

Main Methods:

  • A cross-sectional study included 180 hospitalized CKD patients (ages 20-80) not on renal replacement therapy.
  • Hepatitis C was screened using third-generation ELISA, with positive cases confirmed by Hepatitis C RNA PCR.

Main Results:

  • The prevalence of Hepatitis C among CKD patients was 27.2% (49/180) by ELISA.
  • Of those positive by ELISA, 74.4% (29/39) were confirmed by PCR.
  • Common comorbidities included hypertension (84.4%) and diabetes mellitus (62.8%).

Conclusions:

  • A substantial proportion of hospitalized CKD patients in Pakistan are infected with Hepatitis C.
  • Implementing universal infection control measures in nephrology wards is crucial to prevent Hepatitis C transmission.
Abstract

Keywords:
Chronic Kidney DiseaseFrequencyHepatitis C

More Related Videos

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...