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Related Experiment Videos

Cognitive dysfunction in patients with Systemic Lupus Erythematosus.

Bilal Azeem Butt1, Sumaira Farman2, Saira Elaine Anwer Khan3

  • 1Bilal Azeem Butt, FCPS (Medicine). Division of Rheumatology, Fatima Memorial Hospital, Lahore, Pakistan.

Pakistan Journal of Medical Sciences
|April 4, 2017
PubMed
Summary

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Two-thirds of Pakistani patients with Systemic Lupus Erythematosus (SLE) experience cognitive dysfunction. Early recognition and treatment are crucial for improving the quality of life for individuals with SLE.

Area of Science:

  • Rheumatology
  • Neuroscience
  • Public Health

Background:

  • Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with potential multi-organ involvement.
  • Cognitive dysfunction is a recognized but often underdiagnosed complication of SLE.
  • Understanding the prevalence of cognitive impairment in specific populations is essential for targeted interventions.

Purpose of the Study:

  • To determine the frequency of cognitive dysfunction in a Pakistani population diagnosed with SLE.
  • To assess cognitive function using a standardized tool in a tertiary care rheumatology setting.

Main Methods:

  • A cross-sectional study involving 43 SLE patients meeting SLICC criteria.
  • Cognitive function assessed via Montréal Cognitive Assessment (MoCA) questionnaire, with scores adjusted for education.
Keywords:
Cognitive dysfunctionMontréal Cognitive Assessment (MoCA)Systemic Lupus Erythematosus (SLE)Systemic Lupus International Collaborating Clinics (SLICC)

Related Experiment Videos

  • Data analyzed using SPSS to calculate the frequency of cognitive dysfunction.

    • Main Results:

    • 65.1% of SLE patients (n=28) exhibited cognitive dysfunction based on MoCA scores.
    • The majority of participants (95.3%) were female, with a mean age of 28.72 years.
    • Cognitive dysfunction was more prevalent in patients with less than 12 years of formal education (74.1%).

    Conclusions:

    • A significant majority of SLE patients in this Pakistani cohort presented with cognitive dysfunction.
    • There is a critical need for early identification and management of cognitive impairment in SLE.
    • Addressing cognitive dysfunction can lead to improved quality of life for SLE patients.