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Melasma Associated with Topical Estrogen Cream.
Alyson Snyder1, Rachel A Schiechert2, Martin N Zaiac3
1Traditional Rotating Intern, Broward Health Medical Center, Fort Lauderdale, Florida.
The Journal of Clinical and Aesthetic Dermatology
|April 4, 2017
Summary
Topical estrogen cream can cause melasma, a skin hyperpigmentation condition. This is the first reported case linking topical estrogen use to melasma development, highlighting a potential side effect.
Area of Science:
- Dermatology
- Endocrinology
Background:
- Melasma is a common facial hyperpigmentation disorder.
- Systemic hormones are known triggers for melasma.
- Topical estrogens are used for skin rejuvenation in postmenopausal women.
Observation:
- A 47-year-old woman developed hyperpigmented patches on her upper extremities.
- The patient had been applying topical estrogen cream to the affected areas.
Findings:
- The patient was diagnosed with melasma secondary to topical estrogen cream use.
- This case is the first documented instance of melasma associated with topical estrogen application.
Implications:
- Topical estrogen preparations should be considered a potential cause of melasma.
- Clinicians should discuss melasma as a possible side effect of both topical and systemic estrogens.
- This finding expands the understanding of melasma triggers beyond systemic hormonal influences.