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Related Experiment Videos

Melasma Associated with Topical Estrogen Cream.

Alyson Snyder1, Rachel A Schiechert2, Martin N Zaiac3

  • 1Traditional Rotating Intern, Broward Health Medical Center, Fort Lauderdale, Florida.

The Journal of Clinical and Aesthetic Dermatology
|April 4, 2017
PubMed
Summary

Topical estrogen cream can cause melasma, a skin hyperpigmentation condition. This is the first reported case linking topical estrogen use to melasma development, highlighting a potential side effect.

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Area of Science:

  • Dermatology
  • Endocrinology

Background:

  • Melasma is a common facial hyperpigmentation disorder.
  • Systemic hormones are known triggers for melasma.
  • Topical estrogens are used for skin rejuvenation in postmenopausal women.

Observation:

  • A 47-year-old woman developed hyperpigmented patches on her upper extremities.
  • The patient had been applying topical estrogen cream to the affected areas.

Findings:

  • The patient was diagnosed with melasma secondary to topical estrogen cream use.
  • This case is the first documented instance of melasma associated with topical estrogen application.

Implications:

  • Topical estrogen preparations should be considered a potential cause of melasma.

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  • Clinicians should discuss melasma as a possible side effect of both topical and systemic estrogens.
  • This finding expands the understanding of melasma triggers beyond systemic hormonal influences.