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Related Experiment Videos

Multiple Calcifying Pseudoneoplasms of the Neuraxis.

Leonardo B Brasiliense1, Dennis W Dickson2, Raouf E Nakhleh2

  • 1Neurosurgery, Division of Neurosurgery, University of Arizona, Tucson, AZ.

Cureus
|April 4, 2017
PubMed
Summary
This summary is machine-generated.

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Calcifying pseudoneoplasms of the neuraxis (CAPNONs) can present as multiple lesions, challenging prior understanding. This case highlights potential origins linked to prior brain insults, expanding diagnostic considerations for intra-axial calcified masses.

Area of Science:

  • Neuropathology
  • Neuro-oncology
  • Radiology

Background:

  • Calcifying pseudoneoplasms of the neuraxis (CAPNONs) are exceptionally rare intracranial tumors.
  • Historically, CAPNONs have been reported exclusively as solitary calcified masses.

Observation:

  • This report details the first known case of multiple intra-axial CAPNONs in a 67-year-old woman with a history of seizures.
  • Imaging revealed two heterogeneous intracranial masses, with the supratentorial lesion exhibiting more aggressive features.
  • Histopathological analysis confirmed CAPNONs, characterized by chondromyxoid nodules, calcifications, and osseous metaplasia.

Findings:

  • The patient's history included multiple brain abscesses and a mycotic aneurysm, suggesting a potential link between prior infections and CAPNON development.
Keywords:
benigncalcified pseudoneoplasmsupratentorialtumor

Related Experiment Videos

  • Post-resection, the patient remained seizure-free with no signs of recurrence at four months.
  • Intracranial CAPNONs can manifest as multiple lesions, contrary to previous reports.

    • Implications:

    • Clinicians should consider CAPNONs in the differential diagnosis for intra-axial calcified masses, especially in patients with a history of brain infections.
    • The findings suggest that CAPNONs may arise from abnormal proliferative responses to brain tissue injury.
    • This case expands the understanding of CAPNON presentation and potential etiology.