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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.3K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.3K
Epigenetic Regulation01:37

Epigenetic Regulation

3.6K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.6K
Gene-Environment Interactions01:20

Gene-Environment Interactions

955
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.2K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.2K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

36.5K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.5K
Histone Modification02:32

Histone Modification

15.6K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Related Experiment Videos

Population Epigenetics.

John M Greally1

  • 1Department of Genetics, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Bronx NY 10461, USA, Telephone: +1 718 678 1234.

Current Opinion in Systems Biology
|April 4, 2017
PubMed
Summary
This summary is machine-generated.

Epigenetics research is advancing, focusing on genome regulation and its role in disease. Studying human populations, including health disparities, offers insights but requires careful design to manage confounding factors.

Related Experiment Videos

Area of Science:

  • Epigenetics and human population studies.

Background:

  • The field of epigenetics is maturing, with growing interest in genome regulation.
  • Aberrant epigenetic reprogramming is implicated in disease phenotypes.
  • Understanding epigenetic mechanisms in human populations is crucial for disease etiology.

Purpose of the Study:

  • To explore the application of current epigenetic technologies in human population studies.
  • To investigate the potential of these studies in understanding disease mechanisms and consequences.
  • To examine the challenges and considerations when studying epigenetics in the context of health care disparities.

Main Methods:

  • Applying current epigenetic technologies and insights.
  • Studying human populations, including diverse demographic groups.
  • Careful study design, execution, and interpretation are emphasized.

Main Results:

  • Potential for gaining new insights into disease mechanisms and consequences.
  • Identification of specific population vulnerabilities to certain conditions.
  • Highlighting the significant impact of confounding influences in population-based epigenetic studies.

Conclusions:

  • Epigenetic studies in human populations can yield valuable insights into disease.
  • Addressing health care disparities through epigenetics requires careful consideration of confounding factors.
  • Rigorous study design and interpretation are essential for reliable findings in population epigenetics.