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Depression, antidepressants and driving safety.

Linda L Hill1, Vanessa L Lauzon2, Elise L Winbrock3

  • 1Department of Family Medicine and Public Health, San Diego, USA. llhill@ucsd.edu.

Injury Epidemiology
|April 4, 2017
PubMed
Summary

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Depression and antidepressants significantly increase the risk of motor vehicle crashes. This review highlights the potential driving hazards associated with these conditions and their treatments, emphasizing the need for further research.

Area of Science:

  • Psychiatry
  • Public Health
  • Epidemiology

Background:

  • Depression and its treatments are common.
  • Motor vehicle crashes (MVCs) are a significant public health concern.

Purpose of the Study:

  • To review associations between depression, antidepressants, and motor vehicle crashes.
  • To synthesize evidence on driving risks in individuals with depression and/or using psychotropic medications.

Main Methods:

  • Systematic literature review of epidemiological studies (19 studies: 17 case-control, 2 cohort).
  • Inclusion of studies published between January 1995 and October 2015.
  • Analysis focused on crash risk in naturalistic settings.

Main Results:

Keywords:
AntidepressantsCrashesDepressionDrivingIntentional crashes

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  • Depression was associated with a 2-fold increased crash risk (summary OR = 1.90).
  • Antidepressants were linked to a 40% increased crash risk (summary OR = 1.40).
  • Specific antidepressant classes showed potential to impair driving safety, with elevated odds ratios for all and fatal crashes.

    • Conclusions:

    • Depression and antidepressant use may pose a significant hazard to driving safety.
    • The combined effect of depression and antidepressants on driving risk requires further investigation.
    • Understanding individual contributions of depression and medication is crucial for safety interventions.