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Related Experiment Videos

Ophthalmic Evaluation in Beta-Thalassemia.

Rashid H Merchant1, Hrishikesh Punde2, Neepa Thacker3

  • 1Department of Pediatrics, Nanavati Super-Speciality Hospital, Vile Parle (West), Mumbai, Maharashtra, 400056, India. deandoc2000@hotmail.com.

Indian Journal of Pediatrics
|April 4, 2017
PubMed
Summary

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Ocular manifestations in beta-thalassemia correlate with patient age, not iron levels or treatment. Electroretinography (ERG) shows promise for screening and monitoring retinal function in these patients.

Area of Science:

  • Ophthalmology
  • Hematology
  • Genetics

Background:

  • Beta-thalassemia is a genetic blood disorder requiring chronic transfusions.
  • Transfusions and iron overload can lead to systemic complications, including ocular issues.
  • Ocular manifestations in beta-thalassemia patients need further investigation regarding influencing factors.

Purpose of the Study:

  • To investigate the association between ocular manifestations in beta-thalassemia.
  • To correlate these findings with patient age, transfusion history, serum ferritin, and iron chelation therapy.
  • To evaluate the utility of Optical Coherence Tomography (OCT) and Electroretinography (ERG) in detecting ocular changes.

Main Methods:

  • Cross-sectional analysis of 60 multi-transfused beta-thalassemia patients (12-18 years old).
Keywords:
Beta-thalassemiaElectroretinographyOptical coherence tomography

Related Experiment Videos

  • Ophthalmic examination, B-scan ultrasonography, OCT, and ERG (flash and pattern) were performed.
  • Evaluated retinal photoreceptor and retinal pigment epithelium function via ERG a-wave and p50 wave amplitudes.

    • Main Results:

    • Ocular changes were observed in 38.3% of patients.
    • A significant correlation was found between ocular findings and increasing age (p=0.045).
    • No significant correlation was noted with serum ferritin, transfusion requirements, or chelation therapy. Refractive errors (myopia, astigmatism) were common (23%).

    Conclusions:

    • Increasing age is significantly associated with ocular manifestations in beta-thalassemia patients.
    • Serum ferritin, transfusion burden, and chelation therapy did not show a significant correlation.
    • ERG is a valuable tool for screening and monitoring retinal function in beta-thalassemia.