Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multiple functions of autophagy during development].

Céline Jenzer1, Renaud Legouis1

  • 1Institut de biologie intégrative de la cellule (I2BC), CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, avenue de La Terrasse, 91198 Gif-sur-Yvette Cedex, France.

Medecine Sciences : M/S
|April 4, 2017
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bi-allelic ATG12 variants impair autophagy and cause a neurodevelopmental disorder.

American journal of human genetics·2026
Same author

Reticulon-dependent ER-phagy mediates adaptation to heat stress in C. elegans.

Current biology : CB·2025
Same author

Sulfur starvation-induced autophagy in Saccharomyces cerevisiae involves SAM-dependent signaling and transcription activator Met4.

Nature communications·2024
Same author

Membrane localization of LGG-1/GABARAP is dispensable for autophagy in <i>C. elegans</i>.

Autophagy·2023
Same author

LGG-1/GABARAP lipidation is not required for autophagy and development in <i>Caenorhabditis elegans</i>.

eLife·2023
Same author

Analysis of ATG8 Family Members Using LC3-Interacting Regions (LIR)-Based Molecular Traps.

Methods in molecular biology (Clifton, N.J.)·2022

Autophagy, a cellular degradation process, is vital for development and programmed cell death. It supports fetal growth, sperm development, and stress resistance by recycling cellular components.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Autophagy is a fundamental cellular mechanism for degrading cytoplasmic components via lysosomes.
  • This process is crucial for maintaining cellular homeostasis and responding to stress.
  • Its role in development and programmed cell death is increasingly recognized.

Purpose of the Study:

  • To elucidate the multifaceted roles of autophagy in various biological processes.
  • To highlight the significance of autophagy in developmental stages and stress conditions.
  • To explore the mechanisms by which autophagy influences cellular fate.

Main Methods:

  • Literature review of studies in model organisms.
  • Analysis of autophagy's involvement in mitochondrial degradation, fetal growth, and starvation resistance.

Related Experiment Videos

  • Examination of autophagy's role in programmed cell death.

    • Main Results:

    • Autophagy is essential for specific developmental events, including sperm development and fetal growth.
    • It plays a critical role in programmed cell death.
    • Autophagy contributes to energy production during nutrient starvation and stress.

    Conclusions:

    • Autophagy is a key regulator of cellular processes, impacting development, stress response, and cell survival.
    • Its selective degradation of proteins and organelles is critical for normal development.
    • Understanding autophagy provides insights into cellular adaptation and programmed cell death.