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[Autophagy in chronic liver diseases: a friend rather than a foe?]
Philippe Gual1, Hélène Gilgenkrantz2, Sophie Lotersztajn3
1Inserm, U1065, C3M, Team 8 "Hepatic complications in obesity", Nice, France - Université Nice Côte d'Azur, Inserm, C3M, Nice, France.
Abstract:
Within recycling damaged cell components, autophagy maintains cell homeostasis. Thus, it has been anticipated that autophagy would play an essential role in the pathogenesis of chronic liver diseases. Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most prevalent chronic liver diseases in Western countries, sharing common histopathologic features and a common disease progression. In this review, we discuss the role of autophagy at different stages of NAFLD and ALD as well as in liver regeneration and hepatocarcinogenesis.