Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bypass surgery for chronic lower limb ischaemia.

George A Antoniou1, George S Georgiadis2, Stavros A Antoniou3

  • 1Department of Vascular and Endovascular Surgery, The Royal Oldham Hospital, Pennine Acute Hospitals NHS Trust, Manchester, UK.

The Cochrane Database of Systematic Reviews
|April 4, 2017
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endovascular Abdominal Aortic Aneurysm Repair in High Risk Patients: An Updated Meta-Analysis.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026
Same author

Systematic Review, Meta-analysis, and Trial Sequential Analysis of Randomised Controlled Trials Comparing Balloon Expandable with Self Expanding Stents for the Treatment of Iliac Artery Occlusive Disease.

EJVES vascular forum·2026
Same author

Abdominal Aortic Aneurysm in Women: Under Studied, Under Diagnosed, and Under Screened?

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026
Same author

Surveillance after Endovascular Aneurysm Repair Is Not One Size Fits All: The Central Role of Sac Shrinkage.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2026
Same author

Abdominal Aortic Aneurysm in Women and Men: A Systematic Review of Sex-Specific Outcomes in the United Kingdom.

Annals of vascular surgery·2025
Same author

European Society for Vascular Surgery (ESVS) 2026 Clinical Practice Guidelines on the Management of Descending Thoracic and Thoraco-Abdominal Aortic Diseases - Editor's Choice.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2025

Bypass surgery is a key treatment for critical lower limb ischemia (CLI). While it offers higher technical success and one-year patency compared to angioplasty (PTA), PTA involves fewer complications and shorter hospital stays for CLI patients.

Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Critical Limb Ischemia Treatment

Background:

  • Bypass surgery is a primary treatment for critical lower limb ischemia (CLI).
  • This review is an update of a previous analysis first published in 2000.
  • The study focuses on evaluating the effectiveness of bypass surgery for CLI.

Purpose of the Study:

  • To assess the effects and outcomes of bypass surgery in patients diagnosed with chronic lower limb ischemia.
  • To compare bypass surgery against various control treatments, including angioplasty, endarterectomy, and thrombolysis.

Main Methods:

  • A systematic review of randomized controlled trials (RCTs) was conducted.
  • Searches were performed in the Cochrane Vascular Group trials register and CENTRAL database.

Related Experiment Videos

  • Primary outcomes included complications, mortality, amputation rates, patency, and clinical improvement.

    • Main Results:

    • Bypass surgery showed higher technical success rates and one-year primary patency compared to percutaneous transluminal angioplasty (PTA).
    • PTA was associated with fewer peri-interventional complications and shorter hospital stays for CLI patients.
    • No significant differences were found in amputation rates or mortality between bypass surgery and PTA.

    Conclusions:

    • Evidence quality for bypass surgery comparisons is limited, with no trials comparing it to optimal medical treatment.
    • PTA may be preferable for CLI patients with significant comorbidities due to lower complication rates and shorter hospital stays.
    • Further large-scale trials are needed to clarify the impact of disease characteristics on treatment effectiveness.