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Updated: Jul 2, 2026

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Initial Decomposition Pathways of Aqueous Hydroxylamine Solutions
Yu-Ichiro Izato1, Mitsuo Koshi1, Atsumi Miyake1
1Institute of Advanced Sciences, Yokohama National University , 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan.
Abstract:
This work examined the reaction pathways involved in the initial decomposition of aqueous hydroxylamine solutions via the overall reaction, 2NH2OH → NH3 + HNO + H2O, using quantum chemistry calculations incorporating solvent effects. Several possible decomposition mechanisms were identified and investigated: three neutral-neutral bimolecular, two water-catalyzed, one neutral trimolecular, two ion-neutral bimolecular, and one cation-catalyzed. Optimized structures for the reactants, products, and transition states were obtained at the ωB97XD/6-311++G(d,p)/SCRF = (solvent = water) level of theory, and the total electron energies of such structures were calculated at the CBS-QB3 level of theory. The cation-catalyzed reaction 2NH2OH + NH3OH+ → NH4+ + HNO + H2O + NH2OH (maximum energy barrier (ΔE0‡) = 53.6 kJ/mol) and the anion-neutral bimolecular reaction NH2OH + NH2O- → NH3 + 1NO- + H2O (ΔE0‡ = 79.0 kJ/mol) were both found to be plausible candidates for the dominant step in the initial decomposition. The results of this study indicate that both acidic and basic conditions can affect the thermal stability of hydroxylamine in water.
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