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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Updated: Jun 27, 2026

Synthesis of Poly(N-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Microencapsulation and Stimuli-Responsive Controlled Release of Particles Using Water-in-Air Powders.

Krishna Panthi1, Robin Singh1, Kishore K Mohanty1

  • 1Department of Petroleum and Geosystems Engineering, The University of Texas at Austin , Austin, Texas 78712, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|April 4, 2017
PubMed
Summary

We developed a simple method to encapsulate hydrophilic particles (HP) in water-in-air powders using silica nanoparticles. These encapsulated HP can be released using specific stimuli, showing potential for petroleum engineering applications.

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Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Area of Science:

  • Materials Science
  • Chemical Engineering

Background:

  • Encapsulation of hydrophilic particles (HP) is crucial for controlled delivery in various applications.
  • Existing methods may lack efficiency or stimuli-responsive release capabilities.

Purpose of the Study:

  • To develop a facile, one-step method for encapsulating micro- or nanosize HP.
  • To create a stimuli-responsive system for controlled release of encapsulated HP.
  • To explore the potential of this technology in subsurface petroleum engineering.

Main Methods:

  • A one-step water-in-air powder formation method was employed.
  • Hydrophobic silica nanoparticles were self-assembled around aqueous droplets containing HP under high shear.
  • Stimuli-responsive release was investigated using pH and surfactant solutions.
  • Contact angle studies were used to analyze surface hydrophobicity changes.

Main Results:

  • Successful encapsulation of HP within a silica shell was achieved.
  • Stimuli-responsive release of HP was demonstrated by altering the silica shell's wettability.
  • Contact angle measurements confirmed the effect of stimuli on surface hydrophobicity.

Conclusions:

  • A novel, facile method for encapsulating HP in water-in-air powders was established.
  • The developed system offers stimuli-responsive controlled release of encapsulated materials.
  • This technology holds significant promise for applications in subsurface petroleum engineering, including conformance control and acid stimulation.