Synthesis and Evaluation of a 64Cu-Conjugate, a Selective δ-Opioid Receptor Positron Emission Tomography Imaging Agent
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Azadeh Pirisedigh1, Véronique Blais1, Samia Ait-Mohand1
1Department of Nuclear Medicine and Radiobiology, ‡Department of Pharmacology and Physiology, Faculty of Medicine and Health Sciences, and §Laboratoire de Synthèse Supramoléculaire, Department of Chemistry, Faculty of Sciences, Institut de Pharmacologie, Université de Sherbrooke , Centre de recherche du CHUS, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
Abstract:
Given the putative selectivity of the antagonist TIPP (Tyr-Tic-Phe-Phe) for δ-opioid receptors (DOP), this compound was selected for the design of a novel 64Cu-radiolabeled potent and selective DOP positron emission tomography (PET) imaging agent. Ex vivo autoradiography of TIPPD-PEG-K(NOTA/64Cu)-NH2 on rat brain sections produced a distribution pattern consistent with the known expression of DOP. Taken together, the in vitro and ex vivo data indicate that this 64Cu-tracer holds promise for studying the DOP by means of PET.