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Bioactive Pentacyclic Triterpene Ester Derivatives from Alnus viridis ssp. viridis Bark
Miroslav Novakovic1, Jasmina Nikodinovic-Runic1, Jovana Veselinovic1
1Institute of Chemistry, Technology and Metallurgy, ‡Institute of Molecular Genetics and Genetic Engineering, §Institute for Biological Research "Sinisa Stankovic", and ⊥Faculty of Chemistry, University of Belgrade , 11000 Belgrade, Serbia.
Abstract:
Seven derivatives of pentacyclic triterpene acids (1-7) were isolated from the bark of Alnus viridis ssp. viridis using a combination of column chromatography and semipreparative HPLC. Compounds 1-3, 6, and 7 were determined to be new after spectroscopic data interpretation and were assigned as 27-hydroxyalphitolic acid derivatives (1-3), a 27-hydroxybetulinic acid derivative (6), and a 3-epi-maslinic acid derivative (7), respectively. Pentacyclic triterpenoids with a C-27 hydroxymethyl group have been found in species of the genus Alnus for the first time. These compounds were subjected to cytotoxicity testing against a number of cancer cell lines. Also, selected pentacyclic triterpenoids were selected as potential inhibitors of topoisomerases I and IIα for an in silico investigation.
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