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Related Experiment Videos

Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour.

Dawei Guo1, Dandan Dou1, Xinyu Li1

  • 1a Pharmaceutical Sciences Research Centre, Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , PR China.

Artificial Cells, Nanomedicine, and Biotechnology
|April 4, 2017
PubMed
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Solid lipid nanoparticles (SLNs) offer a safer way to deliver ivermectin (IVM) through the skin. These SLNs enhance IVM

Area of Science:

  • Pharmaceutical Sciences
  • Nanotechnology
  • Dermatology

Background:

  • Systemic toxicity is a concern with conventional ivermectin (IVM) formulations.
  • Transdermal drug delivery offers a localized and potentially safer alternative.
  • Nanoparticle-based drug carriers are being explored for improved dermal delivery.

Purpose of the Study:

  • To develop solid lipid nanoparticles (SLNs) for transdermal ivermectin (IVM) delivery.
  • To evaluate the stability, drug loading, and release characteristics of IVM-loaded SLNs.
  • To assess the efficacy of SLNs for enhanced dermal permeation of IVM.

Main Methods:

  • Solid lipid nanoparticles (SLNs) were prepared using hot homogenization and ultrasonication.
  • Ivermectin (IVM) was encapsulated within the SLNs.
Keywords:
Solid lipid nanoparticlesivermectintransdermal drug deliveryultrasonic technique

Related Experiment Videos

  • Particle size, shape, stability, encapsulation efficiency (EE), and in vitro release were analyzed.
  • Ex vivo permeation studies across rat skin were conducted.

    • Main Results:

    • SLNs exhibited a spherical shape and good stability.
    • Ivermectin was encapsulated in an amorphous state with high EE, ensuring prolonged release without burst effect.
    • Transdermal permeation of IVM from SLNs was significantly enhanced compared to IVM suspension.
    • The developed SLNs demonstrated efficient dermal delivery of IVM.

    Conclusions:

    • The developed solid lipid nanoparticles (SLNs) are a promising vehicle for transdermal ivermectin (IVM) delivery.
    • SLNs improve IVM permeation through the skin, suggesting potential for scabies treatment.
    • This formulation approach minimizes systemic toxicity risks associated with ivermectin.