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Multicentric Reticulohistiocytosis Mimicking Malignancy on 18F-FDG PET/CT
Masatoshi Hotta1, Ryogo Minamimoto, Daisuke Suzuki
1From the Departments of *Nuclear Medicine, †Dermatology, and ‡Urology, National Center for Global Health and Medicine, Tokyo, Japan.
Abstract:
We report the case of a 75-year-old woman who underwent F-FDG PET/CT to evaluate the recurrence of urothelial carcinoma. PET/CT showed F-FDG-avid muscles and lymph nodes, mimicking recurrence. However, F-FDG uptake was also seen in multiple joints and subcutaneous tissue, representing an uncommon finding for recurrence. Further history taking revealed she had been pathologically diagnosed with multicentric reticulohistiocytosis (MRH) from skin biopsy, and the F-FDG PET/CT findings were consistent with MRH, a rare systemic inflammatory granulomatous disease of unknown etiology. Knowledge of the characteristic F-FDG PET/CT features of MRH is important to differentiate MRH from malignancy.