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Published on: June 17, 2016
Low-Dose N,N-Dimethylformamide Exposure and Liver Injuries in a Cohort of Chinese Leather Industry Workers
1Division of Occupational and Environment Health, College of Public Health, Nantong (Ms Qi, Ms Gu, Ms Sun, Dr Xiao, Dr Lian); and Division of Tai cang Center for Disease Control and Prevention, Tai cang, Suzhou (Mr Gu, Mr Xu, Ms Gu), Jiangsu, China.
Objective:
We assessed the risk of liver injuries following low doses of N,N-dimethylformamide (DMF) below threshold limit values (20 mg/m) among leather industry workers and comparison groups.
Methods:
A cohort of 429 workers from a leather factory and 466 non-exposed subjects in China were followed for 4 years. Poisson regression and piece-wise linear regression were used to examine the relationship between DMF and liver injury.
Results:
Workers exposed to a cumulative dose of DMF were significantly more likely than non-exposed workers to develop liver injury. A nonlinear relationship between DMF and liver injury was observed, and a threshold of the cumulative DMF dose for liver injury was 7.30 (mg/m) year.
Conclusions:
The findings indicate the importance of taking action to reduce DMF occupational exposure limits for promoting worker health.
