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Do Pertussis Vaccines Protect Against Bordetella parapertussis?

Juventila Liko1, Steve G Robison1, Paul R Cieslak1

  • 1Oregon Immunization Program, Oregon Health Authority, Portland, Oregon.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|April 4, 2017
PubMed

Insights

The pertussis vaccine demonstrated significant effectiveness in preventing parapertussis in Oregon children. This suggests the pertussis vaccine may offer cross-immunity against related infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Vaccinology
  • Public Health

Background:

  • Parapertussis is a bacterial respiratory infection.
  • The pertussis vaccine is widely administered to children.
  • Understanding vaccine effectiveness against related pathogens is crucial.

Purpose of the Study:

  • To evaluate the effectiveness of the pertussis vaccine in preventing parapertussis.
  • To assess potential cross-immunity conferred by the pertussis vaccine.

Main Methods:

  • Retrospective analysis of health data from Oregon children aged 2 months to 10 years.
  • Employed two distinct vaccine effectiveness (VE) calculation methodologies.
  • Data collected between 2011 and 2016.

Main Results:

  • Two VE methods estimated effectiveness against parapertussis at 66% (95% CI, 59-75%) and 82% (95% CI, 69-90%).
  • Consistent findings across both methodologies indicate significant protection.
  • Results suggest a notable impact of the pertussis vaccine.

Conclusions:

  • The pertussis vaccine shows considerable effectiveness in preventing parapertussis.
  • Findings support the hypothesis that pertussis vaccination may induce cross-protective immunity.
  • Further research is warranted to confirm cross-immunity mechanisms.

Keywords:
Parapertussisimmunizationpertussisvaccine and vaccine effectiveness.

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