Related Experiment Videos
Two classes of PDGF receptor recognize different isoforms of PDGF
C E Hart1, J W Forstrom, J D Kelly
1Department of Pathology, University of Washington, Seattle 98195.
Science (New York, N.Y.)
|June 10, 1988
Abstract:
Previous studies involving platelet-derived growth factor (PDGF) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB, and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptor as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.