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Related Experiment Videos

Ancient Recombination Events between Human Herpes Simplex Viruses.

Sonia Burrel1,2, David Boutolleau1,2, Diane Ryu3

  • 1National Reference Centre for Herpesviruses, Paris, France.

Molecular Biology and Evolution
|April 4, 2017
PubMed
Summary

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Emerging infectious diseases·2026

Herpes simplex virus 2 (HSV-2) genomes contain HSV-1 DNA fragments, revealing complex evolutionary history. Two main HSV-2 lineages exist, with the globally distributed one showing ancient recombination with HSV-1.

Area of Science:

  • Virology
  • Evolutionary Biology
  • Genomics

Background:

  • Herpes simplex virus 1 (HSV-1) and HSV-2 are distinct but related viruses.
  • The evolutionary history and genetic exchange between HSV-1 and HSV-2 are not fully understood.

Purpose of the Study:

  • To investigate the evolutionary history of HSV-2.
  • To identify genetic recombination events between HSV-1 and HSV-2.

Main Methods:

  • Genome sequencing of 18 HSV-2 isolates.
  • Phylogenomic and genome-wide recombination analyses.

Main Results:

  • All sequenced HSV-2 genomes contained HSV-1 fragments.
  • Two distinct HSV-2 lineages were identified: one predominantly in sub-Saharan Africa and a globally distributed one.
Keywords:
human herpes simplex virusphylogenomicsrecombination

Related Experiment Videos

  • Ancient recombination events with HSV-1 were observed exclusively in the globally distributed HSV-2 lineage.

    • Conclusions:

    • HSV-2 evolution is complex, involving recombination with the human-adapted HSV-1.
    • Coinfections with HSV-1 and HSV-2 may have significant genomic and functional implications.
    • Close monitoring of HSV-1/HSV-2 coinfections is recommended.